Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells (1) The T cell immunoglobulin and mucin domain (TIM) family…

Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures (1) Chronic low back pain (LBP) is caused by…

TIM-1 signaling in B cells regulates antibody production (1) Members of the T cell Ig and mucin (TIM) family have recently been implicated in the…

Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function (1) Intestinal mucosal barriers include not…

Role of Mast Cells in Progressive Renal Diseases (1) Mast cells are tissue-specific multifunctional cells, with diverse phenotypes in different anatomic sites in various species,…

Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses (1) Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles…

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation (1)…

Interleukin-33 safeguards neutrophils in sepsis (1) IL-33 signaling prevented Toll-like receptor (TLR)-mediated downregulation of CXCR2 expression in mouse and human neutrophils, which enhanced neutrophil recruitment…

New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries (1) The innate immune system is phylogenetically conserved and is present in almost…

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells (1) The use of glutaraldehyde is associated with numerous pitfalls:…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 3 (1) C3 Glomerulopathies Dense Deposit Disease Dense deposit disease (DDD) lacks Ig deposits and has little…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 2 (1) Diseases Usually Presenting as GN Postinfectious or Poststreptococcal GN The acute, diffuse exudative and proliferative…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 1 (1) The Innate Immune Response Toll-Like Receptors Toll-like receptors (TLRs) are ancient and ubiquitous pattern recognition…

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface (1) Antibodies to the Gram-negative bacterial surface, induced after natural…

Th17 Cells Promote Autoimmune Anti-Myeloperoxidase Glomerulonephritis(1) The primary antigenic targets of Anti-neutrophil cytoplasmic antibody (ANCA) are found abundantly in azurophilic granules of neutrophils and comprise…

Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis (1) In the context of autoimmunity, IL-1…

Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1(1) The major autoantigen is the noncollagenous domain 1 of the a3-chain of…

A Nephritogenic Rat Monoclonal Antibody to Mouse Amlnopeptidase A. Induction of Massive Albuminuria after a Single Intravenous Injection. (1) The hydrolase dipeptidyl peptidase IV (DPP…

Mouse Monoclonal Antibodies with Anti-A, Anti-B and Anti-A,B Specificities; Some Superior to Human Polyclonal ABO Reagents (1) Using BALB/c mice, a finaI high-dose booster schedule…

Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice (1) Inflammatory bowel diseases (IBDs) are widely believed to be due to…