Absence of IFN-γ or IL-12 Has Different Effects on Experimental Myasthenia Gravis in C57BL/6 Mice (1) Th1 cells have been implicated in the pathogenesis of…
Month: July 2021
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects (1) The development of murine ITP…
Antibody specific for the glycophorin A complex mediates intravenous immune globulin–resistant anemia in a murine model
Antibody specific for the glycophorin A complex mediates intravenous immune globulin–resistant anemia in a murine model (1) Antibodies to red blood cell (RBC) antigens can…
Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain
Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain(1) Even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between…
Protein area occupancy at the center of the red blood cell membrane
Protein area occupancy at the center of the red blood cell membrane (1) The area occupancy of protein and lipid at the center of the…
Expression and regulation of erythrocyte autoantibodies in mice following immunization with rat erythrocytes*
Expression and regulation of erythrocyte autoantibodies in mice following immunization with rat erythrocytes*(1) Mice immunized with rat RBC produce antibodies to their own erythrocytes as…
Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica
Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica (1) Anti-aquaporin 4 antibodies (AQP4-Ab) are specifically detected in patients with neuromyelitis…
Neuromyelitis optica pathogenesis and aquaporin 4
Neuromyelitis optica pathogenesis and aquaporin 4 (1) Neuromyelitis optica (NMO) NMO is a devastating disease affecting primarily young women (relapsing NMO) but either sex can…
Identification of Two Major Conformational Aquaporin-4 Epitopes for Neuromyelitis Optica Autoantibody Binding
Identification of Two Major Conformational Aquaporin-4 Epitopes for Neuromyelitis Optica Autoantibody Binding (1) Neuromyelitis optica (NMO) is an autoimmune demyelinating disease characterized by the presence…
Intrathecal Pathogenic Anti-Aquaporin-4 Antibodies in Early Neuromyelitis Optica
Intrathecal Pathogenic Anti-Aquaporin-4 Antibodies in Early Neuromyelitis Optica (1) Neuromyelitis optica (NMO) is a severe demyelinating disorder that primarily affects the optic nerve and spinal…
Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule
Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule (1) Numerous attempts to develop…
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model (1) N-methyl D-aspartate receptor (NMDAR) antibody-mediated encephalitis commonly presents with features of psychiatric disturbance,…
A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
New model of transient strain-dependent autoimmune thrombocytopenia in mice immunized with rat platelets (1) Mouse immunization with allogeneic platelets triggers the production of alloantibodies that…
Induction of Complement-Fixing Autoantibodies against Type VII Collagen Results in Subepidermal Blistering in Mice
Induction of Complement-Fixing Autoantibodies against Type VII Collagen Results in Subepidermal Blistering in Mice (1) The blister-inducing capacity of Abs to various Ags, including desmosomal…
An Ex Vivo Assay to Assess the Potential of Skin Keratinocytes for Wound Epithelialization
An Ex Vivo Assay to Assess the Potential of Skin Keratinocytes for Wound Epithelialization (1) In vertebrates the epithelial lining of the skin provides a…
A methodological review of induced animal models of autoimmune diseases
A methodological review of induced animal models of autoimmune diseases (1) Animal models of autoimmune diseases refer to two groups, sponta- neous and induced models….
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis (1) Several matrix metallopro- teinases (MMPs) have been implicated in the…
Synergistic Pathogenic Effects of Combined Mouse Monoclonal Anti-Desmoglein 3 IgG Antibodies on Pemphigus Vulgaris Blister Formation
Synergistic Pathogenic Effects of Combined Mouse Monoclonal Anti-Desmoglein 3 IgG Antibodies on Pemphigus Vulgaris Blister Formation (1) Conforma- tional epitope mapping in model mice revealed…
Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor
Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor (1) Antibodies to the acetylcholine receptor…
Induction of Pemphigus Phenotype by a Mouse Monoclonal Antibody Against the Amino-Terminal Adhesive Interface of Desmoglein 3
Induction of Pemphigus Phenotype by a Mouse Monoclonal Antibody Against the Amino-Terminal Adhesive Interface of Desmoglein 3 (1) Pemphigus vulgaris (PV) is a life-threatening autoimmune…