Protein Structure Plays a Critical Role in Peanut Allergen Stability and May Determine Immunodominant IgE-Binding Epitopes (1) Prospective studies have indicated that ∼5% of children…
Month: May 2021
Infection, Pain, and Itch
Infection, Pain, and Itch (1) pain or itch, behavioral mechanisms, these sensations are mediated by nociceptor and pruriceptor neurons, respectively. Nociceptor neurons actively participate in…
Analysis of the Effector Activity of Ara h 2 and Ara h 6 by Selective Depletion from a Crude Peanut Extract
Analysis of the Effector Activity of Ara h 2 and Ara h 6 by Selective Depletion from a Crude Peanut Extract (1) The effect of…
Contribution of Ara h 2 to peanut-specific, immunoglobulin E-mediated, cell activation
Contribution of Ara h 2 to peanut-specific, immunoglobulin E-mediated, cell activation (1) Ara h 1 (63 kD), Ara h 2(17–19 kD doublet) and Ara h…
Redefining the major peanut allergens
Redefining the major peanut allergens (1) The peanut, Arachis hypogaea, is a member of the legume family and is related to beans and peas, but…
The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human immunoglobulin E anti-Der p 1 response
The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the…
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue (1) Dimethylmethylene blue assay was subject to positive interference by poly-anions other than…
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes (1) The SARS-CoV-2 spike ectodomain (S-ECD) folds into a multidomain architecture and includes the…
Preparation of Protein Conjugates via Intermolecular Disulfide Bond Formation
Preparation of Protein Conjugates via Intermolecular Disulfide Bond Formation (1) Protein A containing thiol groups reacts with protein B containing 4-dithiopyridyl groups by a disulfide…
Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination
Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination (1) The clinical efficacy of specific immunotherapy may have two…
Sensitization of Mice with Olive Pollen Allergen Ole e 1 Induces a Th2 Response
Sensitization of Mice with Olive Pollen Allergen Ole e 1 Induces a Th2 Response (1) The major allergen of olive pollen is Ole e 1,…
2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis
2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis (1) Polyarginines and also polyamines are protonated at physiological pH thereby tightly interacting with negatively…
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma (1) In the K7M2 mouse model…
Simple Spectrophotometric Quantification of Urinary Excretion of Glycosaminoglycan Sulfates
Simple Spectrophotometric Quantification of Urinary Excretion of Glycosaminoglycan Sulfates (1) The basic dye 1,9-dimethylmethylene blue (DMB), first studied by Taylor and Jeifree, has been used…
A new basic metachromatic dye, 1:9-DimethylMethylene Blue
A new basic metachromatic dye, 1:9-DimethylMethylene Blue (1) With pectin and potassium chondroitin sulphate the first two dyes show more absorption at what may be…
Quaternary Organization of the Goodpasture Autoantigen, the α3(IV) Collagen Chain
Quaternary Organization of the Goodpasture Autoantigen, the α3(IV) Collagen Chain (1) Goodpasture’s (GP) autoantibodies are specifically targeted to the non-collagenous domain (NC1) of the α3(IV)…
Improved and simple micro assay for sulfated glycosaminoglycans quantification in biological extracts and its use in skin and muscle tissue studies
Improved and simple microassay for sulfated glycosaminoglycans quantification in biological extracts and its use in skin and muscle tissue studies (1) Most sulfated glycosaminoglycans (GAGs)…
Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease
Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease (1) The migration and recruitment of leukocytes is essential for their normal immune response to…
Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy
Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy(1) C3 glomerulopathy (C3G) is a category of kidney diseases that includes dense-deposit disease, C3 glomerulonephritis,…
Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice
Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice (1) The use of incomplete (IFA) and complete Freund adjuvant (CFA), which…