TIM-1 signaling in B cells regulates antibody production (1) Members of the T cell Ig and mucin (TIM) family have recently been implicated in the…

Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function (1) Intestinal mucosal barriers include not…

Role of Mast Cells in Progressive Renal Diseases (1) Mast cells are tissue-specific multifunctional cells, with diverse phenotypes in different anatomic sites in various species,…

Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses (1) Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles…

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation (1)…

Interleukin-33 safeguards neutrophils in sepsis (1) IL-33 signaling prevented Toll-like receptor (TLR)-mediated downregulation of CXCR2 expression in mouse and human neutrophils, which enhanced neutrophil recruitment…

New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries (1) The innate immune system is phylogenetically conserved and is present in almost…

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells (1) The use of glutaraldehyde is associated with numerous pitfalls:…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 3 (1) C3 Glomerulopathies Dense Deposit Disease Dense deposit disease (DDD) lacks Ig deposits and has little…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 2 (1) Diseases Usually Presenting as GN Postinfectious or Poststreptococcal GN The acute, diffuse exudative and proliferative…

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases 1 (1) The Innate Immune Response Toll-Like Receptors Toll-like receptors (TLRs) are ancient and ubiquitous pattern recognition…