Treatment Induces HMGB1 to Promote the Formation of Glioma Stem Cells (1) Glioblastoma multiforme (GBM) is the most common primary brain tumor with the average…

Preparation of F(ab’)2 Fragments from Mouse IgG of Various Subclasses (1) Peptic digestion of immunoglobulins has been widely used for the preparation of fragments of…

Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor (1) , IL-10 possesses immunostimulatory activity for the growth and differentiation of activated B cells, cytokine-activated…

Advances of the experimental models of idiopathic membranous nephropathy (1) Mouse models of idiopathic membranous nephropathy (IMN) Thrombospondin type‐1 domain‐containing 7A‐associated membranous nephropathy (MN) model….

Aberrancy in immunogenicity and cell-surface expression of H-2 antigens on erythrocytes(1) The response of mice to H-2 antigens on red blood cells (RBC) was induced…

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function　(1) The Tim family consists of eight genes in…

Exploring the transcriptome of resident spinal microglia after collagen antibody–induced arthritis (1) Arthritis and autoimmunity research has been fairly balanced in the consideration of both…

Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice (1) In the T-cells from patients with eosinophilic asthma, the…

Sex- and cell-dependent contribution of peripheral high mobility group box 1 and TLR4 in arthritis-induced pain (1) High mobility group box 1 protein (HMGB1) is…

Assessment of disulfide and hinge modifications in monoclonal antibodies (1) Clear focus of pharmaceutical development is on the IgG subtype whereby IgG1, IgG2, and IgG4…

Passive transfer of antibodies to the linear epitope 60 kD Ro 273–289 induces features of Sjögren’s syndrome in naive mice (1) Sjögren’s syndrome (SS) is…

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis (1) Most tissue macrophages are established prebirth and subsequently main- tain themselves through…

TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells (1) Members of the T-cell immunoglobulin– and mucin-domain–containing molecule (TIM) family have roles in…

TIM-1 and TIM-3 Proteins in Immune Regulation (1) TIM-1 The administration of anti-Tim-1 Ab in vivo was shown to increase levels of IL-4 and IFN-γ…

A cellular platform for the evaluation of immune checkpoint molecules (1) Immune checkpoints diminish desired T cell responses and blocking coinhibitory receptors like PD-1 or…

Animal Models for Autoimmune Myocarditis and Autoimmune Thyroiditis(1) The following introduces three animal disease models: two autoimmune myocarditis and one autoimmune thyroiditis, which can be…

Structural relatedness of enteric bacterial porins assessed with monoclonal antibodies to Salmonella typhimurium OmpD and OmpC.(1) The outer membrane (OM) of Salmonella typhimurium and other…

Microbial shifts in the aging mouse gut (1) The human microbiome influences and is influenced by several aspects of the host’s health and development. Different…

Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells (1) The T cell immunoglobulin and mucin domain (TIM) family…

Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures (1) Chronic low back pain (LBP) is caused by…