Passive Transfer of Anti-MPO Antibodies (1) Enhancement of glomerular injury caused by anti-glomerular basement membrane (GBM) antibodies when co-administered with anti-Myeloperoxidase (MPO) serum. Mouse models…

Large-Scale Purification of Myeloperoxidase from HL60 Promyelocytic Cells: Characterization and Comparison to Human Neutrophil Myeloperoxidase (1) Myeloperoxidase (MPO) is a heme-containing protein found in the…

Preparation and Extraction of Insoluble (Inclusion-Body) Proteins from Escherichia coli (1) High level expression of recombinant protein in E.coli leads to the formation of highly…

Thioether-Bonded Constructs of Fab′γ and Fc γ Modules Utilizing Differential Reduction of Interchain Disulfide Bonds (1) It is a benefit for therapeutics if we have…

A novel mouse model for MPO-ANCA-associated glomerulonephritis.(1) Animal models have been used for studying the mechanisms for the development of vasculitis. The SCG/Kj mouse is…

Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3 (1) A 29 kDa neutrophil serine proteinase was identified as an autoantigen of anti-neutrophil cytoplasmic autoantibodies (ANCA)…

Inflammation-associated enterotypes, hostgenotype, cage and inter-individual effectsdrive gut microbiota variation in commonlaboratory mice (1) Mouse disease models are crucial for gut microbiome research. Unfortunately, genetic…

Anti-neutrophil cytoplasm antibodies in Wegener’s granulomatosis recognize an elastinolytic enzyme (1). Anti-neutrophil cytoplasm antibodies (ANCA) is closely associated with Wegener’s granulomatosis. It is important to…